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Bromocriptine and puerperal seizures.

K J Rothman1, D P Funch, N A Dreyer

  • 1Epidemiology Resources Inc, Chestnut Hill, MA 02167.

Epidemiology (Cambridge, Mass.)
|May 1, 1990
PubMed
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Bromocriptine use in the postpartum period was not associated with an increased risk of seizures. This study suggests bromocriptine may even reduce early postpartum seizure risk.

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Neurology

Background:

  • Case reports suggest bromocriptine mesylate may increase postpartum seizure risk.
  • Bromocriptine is used to prevent lactation in the puerperium.

Purpose of the Study:

  • To evaluate the association between bromocriptine use and postpartum seizures.
  • To investigate the safety of bromocriptine in the postpartum period.

Main Methods:

  • Record-based case-control study.
  • Identified 43 women with postpartum seizures and matched 319 controls.
  • Data analyzed from three databases.

Main Results:

  • Overall, bromocriptine use was associated with a 22% lower risk of seizures (relative risk, 0.78).

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  • A small positive association was found for seizures occurring >72 hours postpartum.
  • This was offset by a strong negative association for early-onset seizures.

    • Conclusions:

    • Bromocriptine use does not appear to increase the overall risk of postpartum seizures.
    • Bromocriptine may possess antiseizure activity, with a potential rebound effect upon withdrawal.