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Updated: Jun 9, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2,2,2-Trifluoro-N-(1a,2,7,7a-tetrahydronaphtho[2,3-b]oxiren-3-yl)acetamide by X-ray powder diffraction
1Department of Chemistry, Atomic Energy Commission of Syria (AECS), PO Box 6091, Damascus, Syrian Arab Republic. cscientific@aec.org.sy
Abstract:
The title compound, C(12)H(10)F(3)NO(2), an important precursor in the preparation of benzovesamicol analogues for the diagnosis of Alzheimer's disease, was prepared by the epoxidation of 5,8-dihydronaphthalen-1-amine using 3-chloroperoxybenzoic acid. The structure was determined by X-ray powder diffraction, multinuclear NMR spectroscopy and FT-IR spectroscopy. A pair of molecules form intermolecular N-H...O hydrogen bonds, involving the amino and oxirene groups, to produce a dimer.
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