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Updated: Jun 9, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Cinacalcet effect on severe hyperparathyroidism.

Khalid Al Saran¹, Alaa Sabry, Ahmed Yehia

¹Prince Salman Center for Kidney Disease, Riyadh, Saudi Arabia. Khalid_aln@yahoo.co.uk

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia

|September 4, 2010

Summary

This summary is machine-generated.

Cinacalcet effectively lowers high parathyroid hormone (PTH) levels in hemodialysis patients. While generally well-tolerated, gastrointestinal upset is a notable side effect requiring monitoring.

Related Experiment Videos

Last Updated: Jun 9, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Area of Science:

Nephrology
Pharmacology
Endocrinology

Background:

Secondary hyperparathyroidism is common in hemodialysis (HD) patients.
Elevated parathyroid hormone (PTH) levels contribute to significant morbidity and mortality in CKD patients.

Purpose of the Study:

To evaluate the efficacy and safety of cinacalcet in suppressing PTH in HD patients.
To assess the impact of cinacalcet on serum calcium and phosphorus levels.

Main Methods:

A study involving 20 maintenance HD patients with elevated PTH levels.
Cinacalcet was administered orally, with dosage adjusted based on PTH levels over a 4-month follow-up.
Concomitant use of active vitamin D was permitted.

Main Results:

Significant reduction in mean PTH levels from 93.3 to 46.4 pmol/L (P<0.000).
Target PTH levels (< 31.6 pmol/L) were achieved in 54% of patients.
No significant changes observed in serum calcium or phosphorus levels.

Conclusions:

Cinacalcet is an effective therapy for suppressing PTH in HD patients.
The drug demonstrates favorable management of calcium and phosphorus levels.
Gastrointestinal discomfort is a significant side effect that may lead to discontinuation.