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Updated: May 29, 2026
12:22
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Signaling pathways in renal cell carcinoma
Gowrishankar Banumathy1, Paul Cairns
1Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Cancer Biology & Therapy
|September 4, 2010
Summary
Renal cell carcinoma (RCC) is a lethal cancer resistant to traditional therapies. This review details signaling pathways and genetic alterations crucial for understanding RCC pathogenesis and developing targeted treatments.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Renal cell carcinoma (RCC) is the most lethal genitourinary cancer.
- RCC is generally resistant to chemotherapy and radiation therapy.
- Surgical excision is the primary curative treatment for localized RCC.
Purpose of the Study:
- To review the current knowledge of signaling pathways in RCC.
- To discuss genetic and epigenetic alterations in RCC pathogenesis.
- To highlight emerging therapeutic targets for RCC.
Main Methods:
- Literature review of signaling pathways in RCC.
- Analysis of genetic and epigenetic alterations.
- Summary of current therapeutic strategies and targets.
Main Results:
- Key signaling pathways like VHL, VEGFR, mTOR, HGF/c-MET, and Wnt/β-catenin are critical for RCC growth and survival.
- Mutations in these pathways influence tumor response to therapy.
- Emerging drugs target these specific pathways and angiogenesis.
Conclusions:
- Understanding dysregulated signaling pathways and their genetic alterations is key to advancing RCC treatment.
- Targeted therapies focusing on specific molecular pathways offer promise for improved patient outcomes.
- Further research into these pathways may lead to novel therapeutic strategies for resistant RCC.
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