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Updated: May 29, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Signaling pathways in renal cell carcinoma

Gowrishankar Banumathy1, Paul Cairns

  • 1Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

Cancer Biology & Therapy
|September 4, 2010
PubMed

Insights

Renal cell carcinoma (RCC) is a lethal cancer resistant to traditional therapies. This review details signaling pathways and genetic alterations crucial for understanding RCC pathogenesis and developing targeted treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Renal cell carcinoma (RCC) is the most lethal genitourinary cancer.
  • RCC is generally resistant to chemotherapy and radiation therapy.
  • Surgical excision is the primary curative treatment for localized RCC.

Purpose of the Study:

  • To review the current knowledge of signaling pathways in RCC.
  • To discuss genetic and epigenetic alterations in RCC pathogenesis.
  • To highlight emerging therapeutic targets for RCC.

Main Methods:

  • Literature review of signaling pathways in RCC.
  • Analysis of genetic and epigenetic alterations.
  • Summary of current therapeutic strategies and targets.

Main Results:

  • Key signaling pathways like VHL, VEGFR, mTOR, HGF/c-MET, and Wnt/β-catenin are critical for RCC growth and survival.
  • Mutations in these pathways influence tumor response to therapy.
  • Emerging drugs target these specific pathways and angiogenesis.

Conclusions:

  • Understanding dysregulated signaling pathways and their genetic alterations is key to advancing RCC treatment.
  • Targeted therapies focusing on specific molecular pathways offer promise for improved patient outcomes.
  • Further research into these pathways may lead to novel therapeutic strategies for resistant RCC.

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