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Paroxetine overdose.

Arun K Gupta1, Pankaj Verma, Samir K Praharaj

  • 1Senior Psychiatrist and Head, Department of Psychiatry, Dr Ram Manohar Lohia Hospital, New Delhi.

Indian Journal of Psychiatry
|September 4, 2010
PubMed
Summary
This summary is machine-generated.

This case study shows that a significant overdose of paroxetine, an antidepressant, can be managed safely with supportive care alone. The patient recovered fully, demonstrating paroxetine

Keywords:
Paroxetineoverdoseselective serotonin reuptake inhibitor (SSRI)

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Area of Science:

  • Pharmacology
  • Clinical Toxicology
  • Psychiatry

Background:

  • Paroxetine is a widely prescribed selective serotonin reuptake inhibitor (SSRI) antidepressant.
  • Understanding the safety profile of antidepressants in overdose situations is crucial for clinical management.

Purpose of the Study:

  • To report a case of a significant pure paroxetine overdose.
  • To evaluate the clinical outcome and safety of paroxetine in an overdose scenario.

Main Methods:

  • A case report of an 18-year-old female presenting after a suicide attempt.
  • Documentation of the ingested dose (560 mg of paroxetine) and clinical course.
  • Review of treatment provided (supportive care).

Main Results:

  • The patient ingested 560 mg of paroxetine.
  • No significant adverse events or long-term sequelae were observed.
  • Recovery was achieved with supportive treatment alone.

Conclusions:

  • Pure paroxetine overdose, even at significant doses, appears to have a favorable safety profile.
  • Supportive care may be sufficient for managing paroxetine-induced overdose.
  • This case reinforces the relative safety of paroxetine in overdose situations.