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Related Experiment Video

Updated: Jun 9, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

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Published on: June 2, 2014

Headache attributed to a substance or its withdrawal.

Hans-Christoph Diener1, Zaza Katsarava, Volker Limmroth

  • 1Department of Neurology, University of Duisburg-Essen, Essen, Germany. h.diener@uni-essen.de

Handbook of Clinical Neurology
|September 7, 2010
PubMed
Summary

Medication overuse headache (MOH) affects about 1% of the global population, often stemming from the overuse of common pain relief medications. Preventing MOH requires limiting drug dosages and educating patients and doctors about risks.

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Area of Science:

  • Neurology
  • Epidemiology
  • Pharmacology

Background:

  • Medication overuse headache (MOH) is an increasing global health concern, affecting up to 1% of the general population.
  • It arises from the excessive use of various anti-headache drugs, including analgesics, ergots, triptans, and combination preparations.
  • The clinical presentation of MOH is diverse, ranging from increased headache frequency to chronic daily headaches.

Purpose of the Study:

  • To highlight the prevalence and causes of medication overuse headache (MOH).
  • To discuss the diagnostic criteria and pathophysiology of MOH.
  • To emphasize prevention strategies for MOH.

Main Methods:

  • Review of recent epidemiological studies on medication overuse and MOH prevalence.
  • Analysis of International Headache Society (IHS) classification and diagnostic criteria modifications.
  • Discussion of therapeutic approaches and preventative measures.

Main Results:

  • Epidemiological data indicate that up to 4% of the population in Europe, North America, and Asia overuse analgesics.
  • Approximately 1% of the general population suffers from MOH.
  • Current understanding of MOH pathophysiology remains limited.

Conclusions:

  • MOH is a significant and underestimated global health issue.
  • The primary treatment for MOH is the discontinuation of overused medications.
  • Prevention through restricted drug dosage and patient/physician education is crucial to reduce MOH prevalence.