Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Climatic Influence on COVID-19: Investigating the Role of Temperature and Humidity in the Spread of the Omicron Variant.

GeoHealth·2026
Same author

Evaluating the Utility of Artificial Intelligence in Conducting Systematic Reviews.

Arthroplasty today·2026
Same author

WhatsApp-Supported Teledentistry to Reinforce Oral Health Promotion Among Older Adults Residing in Rural and Urban Areas: Randomized Controlled Trial.

JMIR mHealth and uHealth·2026
Same author

MR KLEAN: a Generalized Acquisition-agnostic LLR k-Space Denoising Method for High-dimensional Imaging.

bioRxiv : the preprint server for biology·2026
Same author

Dopaminergic mechanisms supporting hippocampal postencoding dynamics in humans.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Predictive modeling and spatiotemporal analysis of TB in Argentina: Advancing control efforts through machine learning.

Public health·2026
Same journal

A Field Experiment Testing Whether Accountability Reduces Racial Gaps in Performance Evaluations.

Psychological science·2026
Same journal

Does Testosterone Affect Cognitive Reflection? Evidence From a Double-Blind, Randomized Controlled Study of 1,000 Participants.

Psychological science·2026
Same journal

Does Overconfidence Really Confer Adaptive Benefits to Children's Learning?

Psychological science·2026
Same journal

How Does the Mind Grow? Cross-Cultural Intuitive Theories of Mental Development.

Psychological science·2026
Same journal

Not All Practice Is Created Equal: Longitudinal Evidence From Over 40,000 Chess Players.

Psychological science·2026
Same journal

Eye Glint as a Novel Perceptual Cue in Human Vision.

Psychological science·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Constructing an Olfactometer for Rodent Olfactory Behavior Studies
08:36

Constructing an Olfactometer for Rodent Olfactory Behavior Studies

Published on: April 11, 2025

Right orbitofrontal cortex mediates conscious olfactory perception.

Wen Li1, Leonardo Lopez, Jason Osher

  • 1Department of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA. wenli@psych.wisc.edu

Psychological Science
|September 7, 2010
PubMed
Summary
This summary is machine-generated.

The right orbitofrontal cortex (OFC) is crucial for conscious smell perception. Damage to the right OFC caused smell loss, but "blind smell" persisted, showing the OFC

More Related Videos

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

Combining a Breath-Synchronized Olfactometer with Brain Simulation to Study the Impact of Odors on Corticospinal Excitability and Effective Connectivity
06:13

Combining a Breath-Synchronized Olfactometer with Brain Simulation to Study the Impact of Odors on Corticospinal Excitability and Effective Connectivity

Published on: January 19, 2024

Related Experiment Videos

Last Updated: Jun 9, 2026

Constructing an Olfactometer for Rodent Olfactory Behavior Studies
08:36

Constructing an Olfactometer for Rodent Olfactory Behavior Studies

Published on: April 11, 2025

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

Combining a Breath-Synchronized Olfactometer with Brain Simulation to Study the Impact of Odors on Corticospinal Excitability and Effective Connectivity
06:13

Combining a Breath-Synchronized Olfactometer with Brain Simulation to Study the Impact of Odors on Corticospinal Excitability and Effective Connectivity

Published on: January 19, 2024

Area of Science:

  • Neuroscience
  • Olfactory processing
  • Consciousness research

Background:

  • Understanding the neural basis of conscious perception is a major neuroscience challenge.
  • Research has primarily focused on visual consciousness, neglecting other senses like smell.
  • The orbitofrontal cortex (OFC) is hypothesized to be key for conscious olfactory experience due to its role in odor processing.

Observation:

  • A patient with a right OFC injury experienced complete loss of conscious smell (anosmia).
  • Despite anosmia, the patient demonstrated "blind smell"—unconscious odor detection.
  • This "blind smell" was evidenced by neural activity in the left OFC and autonomic responses to odors.

Findings:

  • The study identified a critical role for the right OFC in conscious olfactory perception.
  • Neural activity in the left OFC and autonomic responses indicate intact, albeit unconscious, odor processing.
  • This dissociation highlights distinct neural substrates for conscious and unconscious olfactory processing.

Implications:

  • These findings suggest the right OFC is essential for translating olfactory signals into conscious awareness.
  • The study provides a unique case study for understanding the neural correlates of consciousness.
  • Further research into OFC function can illuminate mechanisms of sensory consciousness across modalities.