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Increased heat shock protein 72 expression in celiac disease
Erna Sziksz1, Gábor Veres, Adám Vannay
1Department of Gastroenterology-Nephrology, Heim Pal Children's Hospital, Budapest, Hungary. sziksz@gyer1.sote.hu
Journal of Pediatric Gastroenterology and Nutrition
|September 7, 2010
Summary
Heat shock protein 72 (HSP72) is elevated in celiac disease (CD) patients, suggesting a protective role in the gut. Its expression decreases with treatment, indicating potential therapeutic value.
Area of Science:
- Immunology
- Gastroenterology
- Cell Biology
Background:
- Heat shock protein 72 (HSP72) is a chaperone protein with known protective functions.
- HSP72 has demonstrated potential in protecting the epithelial barrier, preventing apoptosis, and regulating immune responses.
Purpose of the Study:
- To investigate the role of HSP72 in the pathology of celiac disease (CD).
Main Methods:
- Collected duodenal biopsy specimens from children with untreated CD, treated CD, and controls.
- Determined mRNA expression, protein levels, and localization of HSP72.
Main Results:
- Elevated HSP72 mRNA and protein levels were observed in both untreated and treated CD patients compared to controls.
- HSP72 expression and protein levels were lower in treated CD patients than in untreated CD patients.
- Intensive HSP72 staining was found in villous enterocytes and immune cells of the lamina propria in untreated CD patients.
Conclusions:
- Increased HSP72 expression and altered localization in CD suggest a protective role against gliadin-induced cytotoxicity.
- HSP72 may contribute to preserving intestinal epithelial barrier integrity through antiapoptotic effects.
- HSP72, as a ligand for TLR2 and TLR4, may enhance innate immune responses and signal cellular injury.
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