Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
Renal Clearance01:23

Renal Clearance

The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic partial nephrectomy is inching toward the gold standard for small renal masses-a narrative review.

Translational andrology and urology·2026
Same author

The evolving role of MRI in abdominopelvic emergencies: from problem-solving to first-line imaging.

Abdominal radiology (New York)·2026
Same author

From Endometriosis to Encapsulation: A Case Report of Endometriosis Causing Sclerosing Encapsulating Peritonitis.

Case reports in obstetrics and gynecology·2026
Same author

Robotic retrocaval ureter repair.

Central European journal of urology·2025
Same author

Postoperative complications, emergency department utilisation, and readmission after radical cystectomy.

Central European journal of urology·2025
Same author

Accuracy is Key: Transrectal Ultrasound Versus Magnetic Resonance Imaging to Determine Prostatic Volume.

Archivos espanoles de urologia·2025

Related Experiment Video

Updated: Jun 9, 2026

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

Percutaneous radiofrequency ablation does not affect glomerular filtration rate.

Joseph A Pettus1, David M Werle, Weston Saunders

  • 1Department of Urology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA.

Journal of Endourology
|September 8, 2010
PubMed
Summary

Percutaneous radiofrequency ablation (pRFA) for kidney tumors does not impact global renal function in the short or intermediate term. Glomerular filtration rate (GFR) remained stable one month and one year post-procedure.

More Related Videos

Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

Related Experiment Videos

Last Updated: Jun 9, 2026

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

Area of Science:

  • Nephrology
  • Interventional Radiology
  • Oncology

Background:

  • Renal parenchymal tumors are often treated with minimally invasive techniques.
  • Percutaneous radiofrequency ablation (pRFA) is a common ablation method.
  • Assessing the impact of pRFA on overall kidney function is crucial for patient management.

Purpose of the Study:

  • To evaluate short- and intermediate-term global renal function after a single percutaneous radiofrequency ablation (pRFA).
  • To assess the effect of pRFA on kidney function in patients with solitary renal parenchymal tumors.

Main Methods:

  • Retrospective review of 62 patients undergoing single pRFA for solitary renal tumors.
  • Glomerular filtration rate (GFR) calculated using the abbreviated Modified Diet for Renal Disease equation at baseline, 1 month, and 1 year.
  • Statistical analysis included Wilcoxon paired rank sum test and linear regression.

Main Results:

  • No significant difference in GFR was observed at 1 month or 1 year compared to baseline.
  • Mean GFR at baseline, 1 month, and 1 year was 55, 58, and 57 cc/minute/1.73 m², respectively.
  • Tumor size, location, and baseline GFR did not significantly affect post-ablation GFR.

Conclusions:

  • A single percutaneous radiofrequency ablation (pRFA) procedure does not adversely affect global renal function.
  • Kidney function remains stable in the short and intermediate term following pRFA for solitary renal tumors.