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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

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Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Multiple sclerosis-associated fatigue.

Lauren B Krupp1, Dana J Serafin, Christopher Christodoulou

  • 1Stony Brook University Medical Center, Department of Neurology, Stony Brook, NY 11794-8121, USA. lkrupp@notes.cc.sunysb.edu

Expert Review of Neurotherapeutics
|September 8, 2010
PubMed
Summary
This summary is machine-generated.

Fatigue significantly impacts multiple sclerosis (MS) patients, affecting daily life and treatment options. While interventions show some promise, understanding the causes and developing targeted therapies for MS fatigue remain critical research areas.

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Last Updated: Jun 9, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
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Published on: February 20, 2020

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

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Published on: May 31, 2016

Area of Science:

  • Neurology
  • Clinical Medicine

Background:

  • Fatigue is a widespread and debilitating symptom in multiple sclerosis (MS).
  • It negatively impacts patients' quality of life, mental health, motor skills, and sleep.
  • Current understanding of MS fatigue pathophysiology is incomplete, complicating treatment.

Purpose of the Study:

  • To review the current landscape of fatigue assessment and management in multiple sclerosis.
  • To highlight the challenges in understanding and treating MS-related fatigue.
  • To emphasize the need for further research into targeted therapies.

Main Methods:

  • Review of existing literature on fatigue in multiple sclerosis.
  • Analysis of current assessment scales for fatigue.
  • Examination of clinical trial outcomes for various fatigue interventions.

Main Results:

  • Multiple rating scales exist for fatigue assessment in MS.
  • Interventions like medication, physical activity, and cognitive-behavioral therapy have shown limited benefits.
  • The underlying mechanisms of fatigue in MS are not fully elucidated.

Conclusions:

  • Effective management of fatigue in multiple sclerosis requires a deeper understanding of its pathophysiology.
  • Development of more targeted and effective therapies is essential.
  • Continued research is crucial to improve patient outcomes and quality of life.