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Diverticular fistulation is associated with nicorandil usage
James McDaid1, Claire Reichl, Ihsan Hamzah
1Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK. jmcdaid@doctors.net.uk
Annals of the Royal College of Surgeons of England
|September 8, 2010
Summary
Nicorandil, a medication for angina, is linked to diverticular fistulation. Patients taking nicorandil were significantly more likely to develop fistulas in diverticular disease.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Diverticular disease is a common condition.
- Nicorandil is a medication used for angina.
- Known side effects of nicorandil include gastrointestinal ulceration.
Purpose of the Study:
- To investigate the potential role of nicorandil as an etiological agent in diverticular fistulation.
Main Methods:
- A case-control study was conducted.
- Patients with diverticular disease-related enteric fistulae were compared to controls with uncomplicated diverticular disease.
- Nicorandil use was assessed in both groups.
Main Results:
- 153 patient case notes were analyzed (69 fistula cases, 84 controls).
- 16% of patients with colonic fistulae were taking nicorandil, versus 2% in the control group (OR 7.8, P=0.008).
- No significant difference in ischemic heart disease rates was observed between groups.
Conclusions:
- Nicorandil is associated with fistula formation in diverticular disease.
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