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Updated: Jun 9, 2026

Efficient iPS Cell Generation from Blood Using Episomes and HDAC Inhibitors
Published on: October 28, 2014
iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to
Veronica Ramos-Mejia1, Martin Muñoz-Lopez, Jose L Garcia-Perez
1Andalusian Stem Cell Bank, Centro de Investigacion Biomedica, CSJA-UGR, Granada, Spain.
Abstract:
Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells (iPSCs) may predispose iPSCs to genomic instability. We encourage stem cell scientists to undertake an extensive characterization and standardization of much larger cohorts of iPSC lines in order to set up rigorous criteria to define safe and stable bona fide iPSCs.
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