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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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[Combined cycloferon treatment of tuberculosis in patients infected with HIV]

A K Ivanov, T V Sologub, A M Panteleev

    Eksperimental'Naia I Klinicheskaia Farmakologiia
    |September 9, 2010
    PubMed

    Outcome of treatment of 102 patients co-infected with HIV and tuberculosis hospitalized at Second Municipal Tuberculosis Hospital (St. Petersburg) is analyzed. The median period of follow up was 8 weeks. In order to select the optimum treatment scheme, all patients were divided into three groups (I-III). Group I (51 patients) received, in addition to antituberculosis medications, cycloferon 600 mg tablets on alternate days. Group II (16 patients) received alpha and gamma interferons (Interal injection, 3 MU and Ingaron injection, 500,000 on alternate days) in combination with antituberculosis medications. Control group III (35 patients) received antituberculosis treatment plus placebo. Assessment of the outcome of TB treatment upon 8 weeks of follow up showed a remarkable improvement of clinical and immunological conditions in the patients who received interferons and cycloferon.

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