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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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A versatile and practical solvating agent for enantioselective recognition and NMR analysis of protected amines

Daniel P Iwaniuk1, Christian Wolf

  • 1Department of Chemistry, Georgetown University, Washington, D C 20057, USA.

The Journal of Organic Chemistry
|September 9, 2010
PubMed

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In proton NMR spectroscopy, primary amines and secondary amines showcase their N–H protons as a broad signal in the chemical shift range between δ 0.5 and 5 ppm. The exact position in this range depends on several factors, including sample concentration, hydrogen bonding, and the type of solvent used. Since amine protons undergo fast proton exchange in solution, the protons are labile and therefore do not participate in any splitting with adjacent protons. Thus, the observed peak is broad and...
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