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Updated: Jun 9, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Performance evaluation and application of molecularly imprinted polymer for separation of carbamazepine in aqueous
Chao-Meng Dai1, Sven-Uwe Geissen2, Ya-Lei Zhang3
1State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, 200092, China; Department of Environmental Technology, Chair of Environmental Process Engineering, Technical University of Berlin, Berlin, Germany.
Abstract:
A molecularly imprinted polymer (MIP) for selective adsorption of carbamazepine (CBZ) in aqueous solution was synthesized by precipitation polymerization using CBZ as a template molecule and methacrylic acid (MAA) as a functional monomer. The performance of the CBZ-MIP was evaluated in terms of selectivity, adsorption capacity, binding characteristics, loading volume, and elution volume. The CBZ-MIP exhibited a high affinity for CBZ over the competitive compound (Diclofenac) and was more suitable to remove low concentrations of CBZ in large-volume water samples. A binding performance experiment indicated that the adsorption of CBZ-MIP was characterized by both specific and non-specific binding interactions. Moreover, the regenerability of the MIP was affirmed in ten sequential cycles of adsorption/desorption without a significant loss in recovery. Finally, the CBZ-MIP was applied to enrich CBZ in environmental water samples, and the CBZ concentrations were subsequently determined using HPLC-UV. The results were in good agreement with corresponding LC-MS/MS data.
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