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Related Concept Videos

Determination of Crystal Structures01:29

Determination of Crystal Structures

In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
High-Performance Liquid Chromatography: Types of Detectors01:15

High-Performance Liquid Chromatography: Types of Detectors

The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte properties and...

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Updated: Jun 9, 2026

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

High-speed crystal detection and characterization using a fast-readout detector.

Jun Aishima1, Robin L Owen, Danny Axford

  • 1Diamond Light Source, Harwell Science and Innovation Campus, Didcot, England.

Acta Crystallographica. Section D, Biological Crystallography
|September 9, 2010
PubMed
Summary
This summary is machine-generated.

A new grid-scan method enables rapid evaluation of large sample volumes using a Pilatus P6M detector. This technique is useful for centering invisible samples and characterizing microcrystals without hardware changes.

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Last Updated: Jun 9, 2026

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Area of Science:

  • Crystallography
  • Materials Science
  • Synchrotron Radiation

Background:

  • Microfocus beamline I24 at Diamond Light Source requires efficient sample analysis.
  • Evaluating large sample volumes and locating microcrystals can be time-consuming.

Purpose of the Study:

  • To develop a novel, fast raster-scanning method for evaluating large sample volumes.
  • To demonstrate the utility of this method for sample centering and microcrystal characterization.

Main Methods:

  • Implemented a raster-scanning technique combining continuous sample translation with fast Pilatus P6M detector readout.
  • Developed a slow-readout detector version for broader applicability.

Main Results:

  • The fast grid-scan tool enables rapid evaluation of large sample volumes.
  • The method successfully centered optically invisible samples.
  • Numerous microcrystals on a mesh-like holder were detected and characterized.

Conclusions:

  • The novel grid-scan method provides an efficient tool for microcrystal analysis at microfocus beamlines.
  • This technique is now in routine use on beamline I24 for common applications.