Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reviewing the Computational Landscape of Drug Repurposing: Evolution from Structure-Based Methods to LLM-Based Methods.

Biomolecules·2026
Same author

Mechanisms and biomarkers of immune checkpoint inhibitor-associated myocarditis: from T cell imbalance to multicellular crosstalk.

Frontiers in immunology·2026
Same author

Integrated physiological responses of Macrobrachium rosenbergii to NaHCO₃ stress: growth inhibition, energy metabolism activation, oxidative injury, and autophagic response.

BMC genomics·2026
Same author

SocialGen: Modeling Multi-Human Social Interaction with Language Models.

Proceedings. International Conference on 3D Vision·2026
Same author

Maraviroc ameliorates doxorubicin-induced atrioventricular block through blocking CCL5-CCR5 interaction in macrophage-cardiomyocyte axis.

European journal of pharmacology·2026
Same author

Dual-trajectories of Systolic Blood Pressure and Modified Life's Essential 8 With Gastrointestinal Cancer and All-Cause Mortality: A Prospective Cohort Study.

Journal of clinical hypertension (Greenwich, Conn.)·2026

Related Experiment Video

Updated: Jun 9, 2026

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

Giant Magnetoresistive Sensors for DNA Microarray.

Liang Xu1, Heng Yu, Shu-Jen Han

  • 1Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305-4045, USA.

IEEE Transactions on Magnetics
|September 28, 2011
PubMed
Summary

Giant magnetoresistive (GMR) sensors offer a cheaper, more sensitive alternative for DNA microarrays. These electronic sensors show promise for rapid, high-sensitivity DNA detection with potential for further improvement.

More Related Videos

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Related Experiment Videos

Last Updated: Jun 9, 2026

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

Area of Science:

  • Biosensors
  • Nanotechnology
  • Molecular Diagnostics

Background:

  • Conventional fluorescent DNA microarray sensors are limited by cost, sensitivity, and signal complexity.
  • There is a need for fully electronic, highly sensitive, and easily integrated DNA detection platforms.

Purpose of the Study:

  • To develop and evaluate Giant Magnetoresistive (GMR) sensors for DNA microarray applications.
  • To compare the performance of GMR sensors against traditional fluorescent sensors for DNA detection.

Main Methods:

  • Utilized a bottom spin valve GMR sensor with a 12% Magnetoresistance (MR) ratio.
  • Employed a double modulation technique for signal detection to minimize noise and interference.
  • Performed DNA assays with target DNA concentrations down to 10 picomolar (pM).

Main Results:

  • GMR sensors demonstrated higher sensitivity and lower cost compared to fluorescent sensors.
  • Achieved a dynamic range of 3 logarithmic units for DNA detection.
  • Observed a logarithmic relationship between magnetic signal and DNA concentration, fitting the Temkin isotherm.

Conclusions:

  • GMR sensors provide a robust, electronic platform for sensitive DNA detection in microarrays.
  • Integration with microfluidics holds potential for enhanced sensitivity (≤1 pM) and reduced assay times (<1 hour).
  • GMR sensors represent a significant advancement for cost-effective and efficient molecular diagnostics.