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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
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Published on: November 30, 2022

The current limitations on tissue banking from an academic perspective.

Barbara K Pierscionek1

  • 1School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, UK. B.Pierscionek@ulster.ac.uk

Cell and Tissue Banking
|September 9, 2010
PubMed
Summary

Establishing human tissue banks is crucial for physiological and pathological research. Overcoming complex ethical reviews and understanding donation variability are key to increasing human tissue supply for scientific advancement.

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Area of Science:

  • Biomedical Research
  • Human Physiology
  • Pathology

Background:

  • Human tissue is essential for accurate physiological and pathological research.
  • Existing tissue banks face challenges in establishment and supply.
  • Academics, clinicians, and the pharmaceutical industry recognize the need for more tissue banks.

Purpose of the Study:

  • To identify obstacles hindering the establishment of human tissue banks.
  • To explore the inter-related causes of perceived low demand and uncertain supply of human tissue.
  • To highlight the need for further research into human tissue donation rates and demographic differences.

Main Methods:

  • Qualitative analysis of challenges in human tissue banking.
  • Review of factors influencing researcher decisions regarding human vs. animal tissue studies.
  • Examination of knowledge gaps concerning human tissue supply and donation variability.

Main Results:

  • Cumbersome ethical procedures deter researchers from using human tissues, leading to reliance on animal models and a false perception of low demand.
  • Insufficient knowledge about donation rates, demographic variations, and organ-specific differences creates uncertainty about human tissue supply.
  • These factors collectively impede the establishment and growth of vital human tissue banks.

Conclusions:

  • Streamlining ethical review processes is necessary to encourage human tissue research.
  • Further investigation into the determinants of human tissue donation is required to improve supply.
  • Addressing these challenges will facilitate the creation of more robust tissue banks, advancing biomedical research.