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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Published on: March 14, 2017

Transfusion in the critically ill: does it affect outcome?

M Roseann Cannon-Diehl¹

¹Department of Anesthesiology, Sanford-MeritCare Healthcare System, MeritCare Hospital, Fargo, North Dakota, USA. roseanncannon@gmail.com

Critical Care Nursing Quarterly

|September 10, 2010

Summary

This summary is machine-generated.

Anemia and red blood cell transfusions are common in critical care. Titrating transfusions based on illness severity, not just hemoglobin levels, improves patient outcomes and reduces transfusion risks.

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Area of Science:

Critical Care Medicine
Transfusion Medicine
Hematology

Background:

Anemia and red blood cell (RBC) transfusions are prevalent in critically ill, trauma, and surgical patients.
Patient tolerance to anemia varies significantly due to comorbidities affecting hemodynamic response.
Defining a universal minimum hemoglobin threshold for transfusion benefit remains elusive.

Purpose of the Study:

To evaluate the optimal strategy for red blood cell transfusion in critically ill patients.
To explore the relationship between hemoglobin levels, transfusion triggers, and patient outcomes.
To identify risks associated with red blood cell transfusions.

Main Methods:

Review of evidence regarding transfusion triggers and patient outcomes.
Analysis of factors influencing anemia tolerance in critical illness.
Examination of complications associated with red blood cell storage and allogeneic transfusion.

Main Results:

Patient outcomes are best improved by titrating transfusion requirements to illness severity parameters.
Arbitrarily defined hemoglobin levels are less effective transfusion triggers.
RBC transfusion complications include bacterial contamination, transfusion-related acute lung injury, and immunomodulation.

Conclusions:

Transfusion decisions should prioritize patient-specific factors and illness severity over fixed hemoglobin thresholds.
Individualized transfusion strategies can optimize outcomes and minimize transfusion-related risks.
Further research is needed to refine transfusion guidelines for diverse patient populations.