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HELLP syndrome with and without eclampsia

Sharon D Keiser1, Michelle Y Owens, Marc R Parrish

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L. Wiser Hospital for Women and Infants, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA.

American Journal of Perinatology
|September 10, 2010
PubMed

Insights

This study found that concurrent eclampsia did not significantly worsen maternal or perinatal outcomes for patients with HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count). Eclampsia does not appear to adversely impact HELLP syndrome pregnancies.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Critical Care Medicine

Background:

  • HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count) is a severe obstetric complication.
  • Concurrent eclampsia in HELLP syndrome pregnancies is a concern for maternal and perinatal outcomes.

Purpose of the Study:

  • To compare pregnancy outcomes in patients with HELLP syndrome with and without concurrent eclampsia.
  • To determine if eclampsia significantly impacts maternal or perinatal outcomes in HELLP syndrome cases.

Main Methods:

  • Retrospective analysis of data from 1981-1996 and 2000-2006.
  • Inclusion of patients with class 1 or 2 HELLP syndrome.
  • Comparison of outcomes between HELLP syndrome with eclampsia (HELLP + E) and HELLP syndrome without eclampsia groups.

Main Results:

  • A total of 693 patients with HELLP syndrome were analyzed, with 70 having concurrent eclampsia.
  • The only significant demographic difference was greater nulliparity in the HELLP + E group.
  • No significant worsening of maternal or perinatal outcomes was detected in the HELLP + E group compared to the HELLP-only group.

Conclusions:

  • Concurrent eclampsia does not appear to significantly worsen maternal or perinatal outcomes in HELLP syndrome pregnancies.
  • In this cohort, eclampsia did not contribute an adverse impact on the course or outcome of HELLP syndrome pregnancies.

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