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[Comparative study of the toxicity of cyanic derivatives and/or aromatic amides]
S L Cheav1, O Foussard-Blanpin
1Laboratoire de Pharmacologie, UFR de Pharmacie, Tours.
Annales Pharmaceutiques Francaises
|January 1, 1990
Abstract:
The toxical potentiality of the cyanic radicle and the detoxicating characteristic of the amide group are studied following the evolution of the benzonitrile and benzamide toxicity when a cyanic or amide radicle is added to the original molecule. This comparative study shows that the presence of amide group has not always given a higher toxicity to the organic molecules that own it. It is the respective localization of the cyanic or amide radicles which appears to play the most important role.