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Flow Cytometric Characterization of Murine B Cell Development
08:25

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Therapeutic implications of advances in our understanding of transitional B-cell development in humans

Santi Suryani1, Stuart G Tangye

  • 1Immunology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst 2010, NSW, Australia.

Expert Review of Clinical Immunology
|September 11, 2010
PubMed

B-cell development is characterized by the progressive maturation of hematopoietic stem cells through several stages to ultimately give rise to the mature B-cell pool that has been selected for reactivity against non-self antigens. Thus, the mature pool of naive B cells is capable of elicting high-affinity responses following natural infection with pathogens or vaccination and provides the host with protective long-lived humoral immunity. However, perturbations during the processes of B-cell development and differentiation can give rise to a diverse array of immunological diseases including autoimmunity, immunodeficiency and malignancy. While we have a very rich understanding of the processes underlying B-cell development in mice, our knowledge of the corresponding events occurring in human B cells is substantially less robust. Here, we overview the latest findings relating to human B cells in health and disease with a particular emphasis on the transitional stage of B-cell development.

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