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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Inhibition of dipeptidyl peptidase 4 regulates microvascular endothelial growth induced by inflammatory cytokines

Wataru Takasawa1, Kei Ohnuma, Ryo Hatano

  • 1Division of Clinical Immunology, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Biochemical and Biophysical Research Communications
|September 11, 2010
PubMed

Insights

CD26/dipeptidyl peptidase 4 (DPP-4) inhibition promotes endothelial growth, potentially aiding circulation recovery in diabetic vascular complications. This finding highlights DPP-4

Area of Science:

  • Endocrinology
  • Vascular Biology
  • Immunology

Background:

  • CD26/dipeptidyl peptidase 4 (DPP-4) is expressed on inflamed capillaries and T cells.
  • DPP-4 inhibitors are used to treat type 2 diabetes.
  • Vascular inflammation is a key factor in diabetic complications.

Purpose of the Study:

  • To investigate the role of CD26/DPP-4 in endothelial biology.
  • To determine the effect of CD26/DPP-4 inhibition on endothelial growth.

Main Methods:

  • Studied CD26 expression on microvascular endothelial cells.
  • Utilized genetic and pharmacological inhibition of CD26/DPP-4.
  • Assessed endothelial growth in vitro and in vivo.

Main Results:

  • Proinflammatory cytokines reduce CD26 expression on endothelial cells.
  • CD26/DPP-4 inhibition enhances endothelial growth.
  • DPP-4 inhibition shows potential in improving local circulation.

Conclusions:

  • DPP-4 inhibition plays a significant role in endothelial growth.
  • DPP-4 inhibition may aid in recovering circulation in diabetic vascular complications.

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