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Effects of metformin on the reproductive system of androgenized female rats

Roberta Rassi Mahamed1, Carla Cristina Maganhin, Ricardo Santos Simões

  • 1Gynecology Department, Federal University of São Paulo, São Paulo, Brazil.

Fertility and Sterility
|September 11, 2010
PubMed

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Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood glucose levels...