Mathematical modelling of metabolic pathways affected by an enzyme deficiency

¹Institut für Biochemie, Bereich Medizin (Charité), Humboldt Universität Berlin.

Biomedica Biochimica Acta

|January 1, 1990

Abstract:

The regulation of metabolic pathways of the red cell affected by an enzyme deficiency is studied on the basis of comprehensive mathematical models. The main steps of such a theoretical approach are outlined considering individual alterations in the kinetic properties of two regulatory enzymes: pyruvate kinase and glucose-6-phosphate dehydrogenase. It is demonstrated that mathematical modelling helps to relate the observed changes of cellular quantities as shortened life-span, or as resistance against oxidative stress to alterations in the metabolic regulation.

Keywords:

metabolic pathway modeling enzyme deficiency effects red blood cell metabolism computational biology

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Abstract:

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