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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Childhood posterior circulation arterial ischemic stroke.
Mark T Mackay1, Sanjay P Prabhu, Lee Coleman
1Children's Neuroscience Centre, Royal Children’s Hospital Melbourne, Melbourne, Australia. mark.mackay@rch.org.au
Stroke
|September 11, 2010
Summary
Childhood posterior circulation arterial ischemic stroke (PCAIS) is often caused by nonprogressive arteriopathies affecting distal segments. Unlike adults, atherosclerosis risk factors are not primary causes, and recurrent strokes are common in children.
Area of Science:
- Pediatric Neurology
- Neurovascular Imaging
- Cerebrovascular Diseases
Background:
- Limited data exist on childhood posterior circulation arterial ischemic stroke (PCAIS).
- Understanding PCAIS in children is crucial for diagnosis and management.
- Comparing childhood PCAIS to adult cases can reveal distinct etiological and topographical patterns.
Purpose of the Study:
- To describe the clinical and radiological features of childhood PCAIS.
- To compare infarct topography, vascular abnormalities, risk factors, and stroke subtypes in children versus adults.
- To identify the primary causes and recurrence patterns of PCAIS in pediatric populations.
Main Methods:
- Prospective identification of children with radiologically confirmed PCAIS (2002-2008).
- Classification of infarcts into proximal, middle, and distal posterior circulation segments.
- Utilized a modified TOAST system for pediatric stroke subtype classification and assessed vascular abnormalities via MRA.
Main Results:
- 34 PCAIS events occurred in 27 children; distal infarcts were most common (25/34).
- Nonprogressive steno-occlusive cerebral arteriopathy was the leading cause (9/27), with MRA showing stenosis or occlusion in 16/25.
- Fifty-two percent of children experienced recurrent strokes (posterior or anterior).
Conclusions:
- Nonprogressive arteriopathies are the predominant cause of childhood PCAIS, typically involving distal segments.
- Atherosclerosis-related risk factors are infrequently implicated in pediatric PCAIS.
- Childhood PCAIS is frequently associated with recurrent cerebrovascular events.
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