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Updated: Mar 21, 2026

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Predicting Outcome After Newborn Stroke: A Lesion Network Mapping Study Leveraging Large-Scale Data.

Claire E Kelly1,2, Jian Chen1, Richard Beare1,3

  • 1Developmental Imaging (C.E.K., J.C., R.B.), Murdoch Children's Research Institute, Melbourne, Australia.

Stroke
|March 20, 2026
PubMed
Summary
This summary is machine-generated.

Predicting cerebral palsy after neonatal stroke is difficult. This study found that disruptions in broader brain functional networks, not just motor regions, correlate with cerebral palsy development in newborns following stroke.

Keywords:
cerebral palsyinfant, newbornmagnetic resonance imagingpediatricsstroke

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Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Medical Imaging

Background:

  • Predicting cerebral palsy (CP) after neonatal stroke is a significant clinical challenge.
  • Neonatal stroke impacts brain development, with CP as a potential outcome.
  • Understanding the neural correlates of CP post-stroke is crucial for early intervention.

Purpose of the Study:

  • To identify novel functional connectome-based predictors of cerebral palsy (CP) following neonatal stroke.
  • To investigate acute brain functional connectivity patterns associated with CP development.
  • To differentiate functional network alterations in neonates with stroke who develop CP versus those who do not.

Main Methods:

  • Segmented stroke lesions from diffusion images of term-born neonates with arterial ischemic stroke.
  • Coregistered lesions and resting-state functional MRI data to a neonatal template.
  • Created a neonatal stroke functional connectome by correlating lesions with gray matter regions.
  • Used linear regressions to compare functional connections between neonates who developed CP and those who did not.

Main Results:

  • Included 85 neonates with stroke (33% developed CP).
  • Identified significantly higher functional correlations between lesions and multiple gray matter regions in neonates who developed CP.
  • Affected regions included basal ganglia, thalamus, cerebellum, frontal, temporal (including hippocampus/amygdala), and insula.

Conclusions:

  • Neonatal stroke-related cerebral palsy is associated with disruptions in widespread functional networks.
  • These networks involve both motor and extramotor regions, extending beyond localized lesion effects.
  • Findings highlight the importance of analyzing broader functional connectome alterations for predicting CP after neonatal stroke.