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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: Jun 8, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

From bench to bedside--translational research in psoriasis.

J C Prinz1

  • 1Department of Dermatology, University of Munich, Munich, Germany. joerg.prinz@med.uni-muenchen.de

Journal of the European Academy of Dermatology and Venereology : JEADV
|September 14, 2010
PubMed
Summary
This summary is machine-generated.

Psoriasis is an autoimmune disease driven by T-cells and the innate immune system. Understanding this immune response, particularly the role of cytokines like IL-12 and IL-23, reveals targets for effective biological therapies.

Related Experiment Videos

Last Updated: Jun 8, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Immunodermatology
  • Autoimmune disease pathogenesis

Background:

  • Psoriasis was historically viewed as a keratinocyte disorder.
  • Current understanding identifies psoriasis as a systemic T-cell mediated autoimmune disease involving the innate immune system.

Purpose of the Study:

  • To elucidate the immunological mechanisms underlying psoriasis pathogenesis.
  • To identify key molecular targets for therapeutic intervention.

Main Methods:

  • Review of current research on psoriasis immunology.
  • Analysis of cellular and molecular pathways involved in psoriatic plaque formation.

Main Results:

  • Psoriasis involves genetic and environmental factors triggering T-cell activation.
  • Cytokines, chemokines, and growth factors drive keratinocyte proliferation and altered differentiation.
  • A cycle of T-cell and antigen-presenting cell activation, involving interleukin 12 (IL-12) and IL-23, perpetuates the disease.

Conclusions:

  • Psoriasis is a complex autoimmune condition with significant immune system involvement.
  • The identified cytokine-driven cycle presents a viable target for biological therapies.