Related Experiment Video
Updated: Dec 26, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.4K
[Psoriasis in dupilumab-treated atopic dermatitis]
Summary
Dupilumab therapy for atopic dermatitis can unmask psoriasis in some patients. Stopping oral steroids alongside dupilumab treatment may trigger this unexpected skin condition.
Area of Science:
- Immunodermatology
- Pharmacology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin disease.
- Dupilumab, a monoclonal antibody, targets the interleukin-4 (IL-4) and IL-13 receptor alpha 1 (IL4R1) pathway, crucial in Th2-driven inflammation characteristic of AD.
Observation:
- A case study of a 40-year-old male patient undergoing dupilumab therapy for atopic dermatitis is presented.
- The patient developed histologically confirmed psoriasis after six weeks of dupilumab treatment.
Findings:
- The development of psoriasis was observed following the initiation of dupilumab.
- The study suggests that the abrupt cessation of non-guideline-based oral steroid therapy, combined with dupilumab's blockade of the Th2 signaling pathway, acted as potential triggers for new-onset psoriasis.
Implications:
- This case highlights a potential, albeit unusual, adverse effect of dupilumab therapy.
- It underscores the importance of considering patient-specific factors, including prior treatments, when initiating immunomodulatory therapies like dupilumab.
- Further investigation into the interplay between dupilumab, steroid withdrawal, and psoriasis development is warranted.
Related Concept Videos
01:23Skin Diseases and Disorders
5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
01:24T Cell Types and Functions
2.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.0K