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Related Experiment Video

Updated: Jun 8, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

CD23/FcεRII: molecular multi-tasking.

M Acharya¹, G Borland, A L Edkins

¹Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, CR-UK Beatson Institute, Glasgow, UK.

Clinical and Experimental Immunology

|September 14, 2010

Summary

This summary is machine-generated.

CD23, a receptor for immunoglobulin E, regulates IgE responses. Soluble CD23 (sCD23) proteins exhibit cytokine-like activities, and understanding CD23 interactions aids therapeutic strategies.

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Last Updated: Jun 8, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

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Published on: October 30, 2015

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

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IP-FCM: Immunoprecipitation Detected by Flow Cytometry

IP-FCM: Immunoprecipitation Detected by Flow Cytometry

Published on: December 2, 2010

Area of Science:

Immunology
Molecular Biology

Background:

CD23 is the low-affinity receptor for immunoglobulin E (IgE).
It plays a crucial role in regulating IgE responses.
CD23 can be cleaved into soluble forms (sCD23) with cytokine-like activities.

Purpose of the Study:

To identify regions of CD23 responsible for ligand interactions.
To elucidate structure-function relationships within the CD23 protein.
To explore CD23 as a therapeutic target.

Main Methods:

Ligand binding assays to identify interaction regions.
Structural analysis of CD23.
Review of translational studies involving CD23.

Main Results:

Regions of CD23 interacting with IgE, CD21, MHC class II, and integrins were identified.
These findings explain CD23's structure-function relationships.
CD23's role in therapeutic antibody effects was highlighted.

Conclusions:

Understanding CD23-ligand interactions is key to its function.
CD23 is a credible target for therapeutic interventions.
CD23 is implicated in the efficacy of certain antibody therapies.