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Updated: Jun 8, 2026

Stimulated Single Fiber Electromyography (SFEMG) for Assessing Neuromuscular Junction Transmission in Rodent Models
Published on: March 8, 2024
Is neuromuscular relaxation of rocuronium prolonged in patients with obstructive jaundice?
Zhenmeng Wang1, Yang Bao, Zhijie Lu
1Department of Anesthesia and Intensive Care, Eastern Hepatobiliary Surgery Hospital, 225# Changhai Road, Shanghai 200438, China.
Abstract:
Rocuronium is an aminosteroid non-depolarizing neuromuscular relaxant, which is metabolized in the liver and excreted through bile. The duration of neuromuscular blockade of rocuronium at equipotent bolus dose may be prolonged and variable in patients with liver and kidney failure. However, very few studies have been reported its pharmacodynamics in patients with obstructive jaundice. We propose that the effect of rocuronium is prolonged in patients with obstructive jaundice, and a caution should be taken in monitoring postoperative residual neuromuscular blockade.
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