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Updated: Jun 8, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Synthesis and antiviral evaluation of α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides
Kohei Yamada1, Hiroyuki Hayakawa, Shinji Sakata
1Biochemicals Division, Yamasa Corporation, Choshi, Chiba, Japan. k_yamada@yamasa.com
Abstract:
We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-α-nucleosides. By applying the method, we have synthesized α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents.
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