Related Experiment Video
Updated: Jun 8, 2026

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
Published on: March 14, 2021
The distribution of phosphatidyl-D-serine in the rat
Taketo Omori1, Hisaaki Mihara, Tatsuo Kurihara
1Institute for Chemical Research, Kyoto University, Kyoto, Japan.
Abstract:
Phosphatidylserine plays an important role in cell membranes. We have reported the occurrence of phosphatidyl-D-serine (D-PS) in the rat cerebrum. Here, we describe the tissue distribution of D-PS in the rat. The D/D+L ratio of D-PS in the cerebrum was 0.9%, while no detectable amount of D-PS was detected in the cerebellum. D-PS was also found in the heart, spleen, lung, testis, liver, and kidney in a range of 0.05-0.7% (the D/D+L ratio). Thus, D-PS, even in small amounts, is localized to the cerebrum in the brain and is distributed to various tissues other than the brain in the rat.
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Asymmetric Lipid Bilayer
Synthesis of Phosphatidylcholine in the ER Membrane
The major components of all eukaryotic cell...
Membrane Lipids
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...

