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Related Concept Videos

Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Pulmonary Embolism I: Introduction01:19

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A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

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Related Experiment Video

Updated: Jun 8, 2026

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
07:29

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats

Published on: March 8, 2019

Pulmonary artery sarcoma.

Shanda H Blackmon1, Michael J Reardon

  • 1Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.

Methodist Debakey Cardiovascular Journal
|September 14, 2010
PubMed
Summary
This summary is machine-generated.

Primary heart sarcomas are rare, with location, not histology, dictating prognosis. A new classification and multimodality approach significantly improved survival for pulmonary artery sarcomas.

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Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
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Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

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Area of Science:

  • Cardiovascular Pathology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Primary heart tumors are rare; malignant primary heart tumors, particularly sarcomas, are even rarer.
  • Histology plays a minimal role in treatment and prognosis for primary cardiac sarcomas; anatomic location is the key determinant.
  • Primary pulmonary artery (PA) sarcomas are exceptionally rare, with limited case reports and unresolved diagnostic and treatment strategies.

Purpose of the Study:

  • To classify primary cardiac sarcomas based on anatomic location (right heart, left heart, PA).
  • To propose a diagnostic strategy, treatment approach, and staging system for primary PA sarcoma.
  • To evaluate the efficacy of a radical resection with curative intent and multimodality approach in improving patient survival.

Main Methods:

  • Systematic study of primary cardiac sarcomas by a specialized cardiac sarcoma group.
  • Surgical intervention on 9 patients with primary PA sarcoma using radical resection and a multimodality approach.
  • Development of a classification system based on tumor location within the heart and PA.

Main Results:

  • Anatomic location (right heart, left heart, PA) is the primary factor influencing clinical presentation, treatment, and prognosis.
  • A multimodality approach including radical resection resulted in substantial improvement in patient survival compared to historical controls for primary PA sarcoma.
  • Fewer than 250 cases of primary PA sarcoma reported in the English literature since 1923, highlighting its rarity.

Conclusions:

  • Primary cardiac sarcomas should be classified by anatomic location.
  • A proposed diagnostic strategy, treatment approach, and staging system for primary PA sarcoma can improve outcomes.
  • Multimodality treatment offers a promising avenue for improving survival in patients with primary PA sarcoma.