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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

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Updated: Jun 8, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Left heart sarcomas.

David C Rice1, Michael J Reardon

  • 1The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Methodist Debakey Cardiovascular Journal
|September 14, 2010
PubMed
Summary
This summary is machine-generated.

Primary cardiac sarcomas are rare, often malignant tumors affecting younger patients. A novel surgical technique involving explantation and ex vivo resection improves outcomes for left heart sarcomas, reducing recurrence and enhancing survival.

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Last Updated: Jun 8, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Area of Science:

  • Cardiovascular Surgery
  • Surgical Oncology
  • Cardiac Pathology

Background:

  • Primary cardiac sarcomas are rare, with malignant forms historically having poor prognoses.
  • Diagnosis can be challenging due to rarity and nonspecific symptoms, with left heart sarcomas often presenting late.
  • Complete surgical resection is the only proven therapy, but local recurrence and poor survival are common, especially for left heart sarcomas.

Purpose of the Study:

  • To evaluate the efficacy of a novel surgical technique for left heart sarcoma.
  • To assess if cardiac explantation, ex vivo tumor resection, and reimplantation can improve resection completeness and patient survival.
  • To present the approach and outcomes for left heart sarcoma from a specialized cardiac sarcoma group.

Main Methods:

  • Review of published literature on primary cardiac sarcoma treatment and outcomes.
  • Implementation and description of the surgical technique: cardiac explantation, ex vivo tumor resection, cardiac reconstruction, and reimplantation/autotransplantation.
  • Analysis of patient outcomes including local recurrence rates and long-term survival.

Main Results:

  • Left heart sarcomas present unique anatomic challenges, limiting access for complete resection with standard approaches.
  • The novel surgical technique aims to overcome these challenges, facilitating more complete tumor removal.
  • Published literature indicates frequent local recurrence and poor long-term survival for left heart sarcomas treated with conventional methods.

Conclusions:

  • Limited anatomic accessibility in the left atrium contributes to incomplete resection and poor outcomes in left heart sarcomas.
  • Cardiac explantation with ex vivo resection offers a potential solution to improve surgical completeness.
  • This approach holds promise for reducing local recurrence and improving survival for patients with left heart sarcoma.