Related Experiment Video
Updated: Jun 8, 2026

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice
Published on: February 24, 2026
[Intravenous IgG for treatment of neuromuscular diseases]
Christian A Vedeler1, Svein Ivar Mellgren, Roald Omdal
1Nevrologisk avdeling, Haukeland universitetssykehus, 5021 Bergen, Norway. christian.vedeler@helse-bergen.no
Background:
Highly purified IgG administered intravenously (IVIG) is used to treat many neurological diseases.
Material And Methods:
This review is based on articles identified through a search in PubMed and the authors' knowledge and experience within the field.
Results:
The effect of IVIG has been best documented in the treatment of acute and chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy and acute exacerbation of myasthenia gravis. Some smaller studies support explorative IVIG treatment in other neurological diseases such as Lambert-Eaton myasthenic syndrome, paraproteinemic neuropathy, neuropathy caused by vasculitis, inflammatory myopathies and stiff-person syndrome.
Interpretation:
IVIG affects the immune system in different ways. Documentation for the effect of such treatment in most neurological diseases remains sparse.
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