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Related Concept Videos

Recombinant DNA01:09

Recombinant DNA

Overview
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

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Related Experiment Video

Updated: Jun 8, 2026

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing
12:21

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing

Published on: January 7, 2019

HSV Recombinant Vectors for Gene Therapy.

Roberto Manservigi1, Rafaela Argnani, Peggy Marconi

  • 1Department of Experimental and Diagnostic Medicine - Section of Microbiology, University of Ferrara, Via Luigi Borsari 46, 44100 Ferrara, Italy.

The Open Virology Journal
|September 14, 2010
PubMed
Summary
This summary is machine-generated.

Herpes simplex virus (HSV) vectors show promise for gene therapy, cancer treatment, and vaccines. Researchers are overcoming delivery challenges for these powerful biomedical tools.

Keywords:
HSVcancergene therapyneurodegenerative disordersoncolytic vectorstargetingvaccines.viral vectors

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Published on: October 30, 2016

Area of Science:

  • Genetics and Molecular Biology
  • Biomedical Engineering
  • Infectious Diseases

Background:

  • Herpes simplex virus (HSV) genetics and molecular biology knowledge enables vector development.
  • HSV vectors offer diverse applications in human healthcare, including gene therapy and cancer treatment.

Purpose of the Study:

  • To review the development and applications of HSV vectors.
  • To summarize challenges in HSV vector delivery and strategies to overcome them.

Main Methods:

  • Review of current research on HSV vector applications.
  • Analysis of strategies for overcoming HSV vector delivery obstacles.

Main Results:

  • Replication-defective HSV vectors are non-toxic gene transfer tools for neural gene therapy.
  • Replication-competent (oncolytic) HSV vectors show potential for brain tumor eradication.
  • HSV vectors are being explored for vaccine development against HSV and other pathogens.

Conclusions:

  • HSV vectors are versatile tools with significant therapeutic potential.
  • Ongoing research addresses delivery challenges to enhance HSV vector efficacy.
  • HSV vectors represent a promising platform for future medical interventions.