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Updated: Jun 8, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

A microfluidic microprocessor: controlling biomimetic containers and cells using hybrid integrated

David Issadore¹, Thomas Franke, Keith A Brown

¹School of Engineering and Applied Science, Harvard University, 29 Oxford Street, Cambridge, MA, USA.

|September 14, 2010

Summary

This study introduces a novel integrated chip for biological and chemical experiments, enabling precise control of cells and reagents. The platform utilizes electric fields for cell manipulation and reagent delivery, paving the way for automated, miniaturized diagnostics and research.

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Area of Science:

Biotechnology
Microfluidics
Integrated Circuits

Background:

Biological and chemical experiments require precise control over cells and reagents.
Current experimental platforms can be complex, expensive, and lack miniaturization.
Need for integrated solutions for high-throughput biological and chemical analyses.

Purpose of the Study:

To develop an integrated platform for performing biological and chemical experiments on a chip.
To enable simultaneous control of thousands of living cells and picoliter fluid volumes.
To miniaturize complex experimental procedures for diagnostics and research.

Main Methods:

Development of a hybrid integrated circuit (IC)/microfluidic chip using standard CMOS technology.
Utilizing phospholipid bilayer vesicles as picoliter containers for reagents.
Employing spatially patterned electric fields generated by 32,768 individually driven metal pixels.
Operating the chip in two modes: MHz frequencies for dielectrophoresis (trapping, moving, deforming) and kHz frequencies for electroporation and electrofusion.

Main Results:

The hybrid chip can trap, move, porate, fuse, and deform individual living cells and vesicles.
Demonstrated capability for complex biological and chemical tasks through serial combination of basic functions.
Enabled high-throughput operations via parallel processing across numerous pixels.
Successful operation in distinct dielectrophoresis and electroporation/electrofusion modes.

Conclusions:

The developed hybrid IC/microfluidic chip offers a versatile platform for advanced biological and chemical experimentation.
This technology represents a significant advancement in miniaturizing experimental capabilities for research and diagnostics.
The platform facilitates automated, high-throughput, and cost-effective biological and chemical analyses on a single chip.