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Updated: Jun 8, 2026

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Recent advances in DNA-based directed assembly on surfaces.

Albert M Hung¹, Hyunwoo Noh, Jennifer N Cha

¹Department of Nanoengineering, University of CA, San Diego, CA, USA.

|September 14, 2010

Summary

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DNA nanotechnology offers a promising alternative to conventional microfabrication for creating small, integrated devices. This review highlights DNA-directed assembly methods for precise nanomaterial patterning and integration with lithography.

Area of Science:

Nanotechnology
Materials Science
Biomolecular Engineering

Background:

Growing demand for smaller, integrated electronic, photonic, and magnetic arrays.
Limitations of conventional microfabrication in terms of resolution and cost.
Potential of biomolecular assembly, especially DNA nanotechnology, due to inherent size and molecular recognition capabilities.

Purpose of the Study:

To review recent advancements in DNA-based directed assembly on substrates.
To explore novel methods for nanomaterial patterning and deposition using DNA.
To discuss the integration of DNA nanostructures as templates for nanoscale component assembly.

Main Methods:

Utilizing DNA nanotechnology for directed assembly of nanomaterials.
Developing novel DNA-modified surfaces for patterning and deposition.

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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Related Experiment Videos

Last Updated: Jun 8, 2026

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Employing synthetic DNA nanostructures (tiles, origami) as templates.

Integrating self-assembly techniques with top-down lithography.

Main Results:

Demonstration of effective DNA-based methods for patterning and depositing nanomaterials.
Successful use of DNA nanostructures to direct the assembly of nanoscale components.
Exploration of hybrid approaches combining self-assembly with lithography.

Conclusions:

DNA-directed assembly presents a viable strategy for nanoscale device fabrication.
Integration of DNA nanotechnology with lithography opens new avenues for advanced materials.
Future work should focus on further refining these hybrid fabrication techniques.