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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Seed migration to the vertebral venous plexus after prostate brachytherapy]
W Wagner1, N Willich, A Radmard
1Strahlenklinik, Paracelsus-Klinik Osnabrück, Am Natruper Holz 69, 49076 Osnabrück, Deutschland. prof.wolfgang.wagner@pk-mx.de
Der Urologe. Ausg. A
|September 14, 2010
Summary
Seed migration to the vertebral venous plexus occurred after low dose rate prostate brachytherapy using Iodine-125. A patient had seeds detected in the venous plexus and lung without symptoms or tissue damage.
Area of Science:
- Oncology
- Radiotherapy
- Medical Physics
Background:
- Low dose rate (LDR) brachytherapy with Iodine-125 ((125)I) is a standard treatment for localized prostate cancer.
- Understanding potential complications, such as radioactive seed migration, is crucial for patient safety and treatment efficacy.
Observation:
- A 74-year-old male patient with prostate adenocarcinoma underwent (125)I LDR brachytherapy.
- Six weeks post-treatment, follow-up imaging revealed one migrated seed in the vertebral venous plexus and another in the right lung.
Findings:
- No evidence of tissue damage was observed around the migrated seeds.
- The patient remained asymptomatic, with no clinical manifestations related to the seed migration.
Implications:
- This case highlights the possibility of asymptomatic seed migration to the vertebral venous plexus and lungs following prostate brachytherapy.
- Further research may be warranted to assess the long-term clinical significance and incidence of such migration events.

