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Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein and Protein Structures

Protein and Protein Structures

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

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Updated: Jun 8, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Template-based protein structure modeling.

¹Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

Methods in Molecular Biology (Clifton, N.J.)

|September 14, 2010

Summary

This summary is machine-generated.

Determining protein 3D structures computationally is crucial due to experimental limitations. This review focuses on template-based modeling, particularly comparative modeling, to predict protein structures effectively.

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Last Updated: Jun 8, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Area of Science:

Structural biology
Bioinformatics
Computational biology

Background:

Protein 3D structure is vital for functional characterization.
Experimental structure determination is time-consuming, with <1% of proteins structurally known.
Computational methods bridge the gap between known protein sequences and 3D structures.

Purpose of the Study:

To review template-based protein structure modeling strategies.
To focus on comparative modeling techniques within the protein structure prediction pipeline.

Main Methods:

Discussion of template-based modeling principles derived from evolutionary theory.
Review of techniques for each major step in the comparative modeling pipeline.

Main Results:

Template-based modeling offers a viable computational approach to protein structure prediction.
Comparative modeling is a key strategy within template-based methods.

Conclusions:

Computational approaches, especially template-based modeling, are essential for protein structure prediction.
Understanding comparative modeling techniques facilitates the prediction of protein structures.