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Related Experiment Video

Updated: Jun 8, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Adaptive servoventilation improves cardiac function and respiratory stability.

Olaf Oldenburg¹, Thomas Bitter, Roman Lehmann

¹Department of Cardiology, Heart and Diabetes Centre North Rhine Westphalia, University Hospital, Ruhr University Bochum, Georgstrasse 11, 32545, Bad Oeynhausen, Germany. akleemeyer@hdz-nrw.de

Clinical Research in Cardiology : Official Journal of the German Cardiac Society

|September 14, 2010

Summary

This summary is machine-generated.

Adaptive servoventilation (ASV) effectively treated Cheyne-Stokes respiration (CSR) in heart failure patients. ASV improved cardiac function and respiratory stability, unlike control groups.

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Last Updated: Jun 8, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Area of Science:

Cardiology
Pulmonology
Sleep Medicine

Background:

Cheyne-Stokes respiration (CSR) significantly impacts prognosis in chronic heart failure (CHF) patients, indicating respiratory instability.
Associated factors include daytime pCO₂, VE/VCO₂-slope, exertional oscillatory ventilation (EOV), and heightened central CO₂ receptor sensitivity.

Purpose of the Study:

To investigate the effects of Adaptive Servoventilation (ASV) on CSR, cardiac function, and respiratory stability in CHF patients.
To compare outcomes between ASV-adherent patients and those who rejected or inconsistently used ASV treatment.

Main Methods:

A total of 105 CHF patients (NYHA ≥ II, LVEF ≤ 40%) with CSR (AHI ≥ 15/h) were followed for 6.7 months.
Patients were divided into ASV-adhered (n=56) and control (n=59) groups based on treatment adherence.
Key parameters assessed included CSR, cardiac function markers, exercise capacity, and respiratory control sensitivity.

Main Results:

ASV effectively treated CSR in the adhered group.
ASV patients showed significant improvements in NYHA class, LVEF, oxygen uptake, 6-minute walking distance, and NT-proBNP compared to controls.
Improvements in pCO₂, VE/VCO₂-slope, EOV, and central CO₂ receptor sensitivity were observed exclusively in ASV-adhered patients.

Conclusions:

ASV therapy can effectively manage CSR in CHF patients.
ASV improves cardiac function, exercise capacity, and respiratory stability in this population.
ASV demonstrates potential to enhance parameters of sleep-disordered breathing (SDB) and overall cardiovascular health in CHF with CSR.