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5-HTTLPR status moderates the effect of early adolescent substance use on risky sexual behavior
Steven M Kogan1, Steven R H Beach, Robert A Philibert
1Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA 30605-4527, USA. smkogan@uga.edu
Objective:
A longitudinal, prospective design was used to investigate a moderation effect in the association between early adolescent substance use and risky sexual behavior 2 years later. A genetic vulnerability factor, a variable nucleotide repeat polymorphism (VNTR) in the promoter region of the serotonin transporter gene SLC6A4, known as 5-HTTLPR, was hypothesized to moderate the link between substance use at age 14 and risky sexual behavior at age 16. This VNTR has been associated with risk-taking behavior.
Design:
African American youths in rural Georgia (N = 185) provided 2 waves of data on their substance use and sexual behavior. Genetic data were obtained via saliva samples.
Main Outcome Measures:
Substance use and sexual risk behavior were assessed using youth self-report items developed for this investigation.
Results:
Multiple regression analyses indicated that the presence of 1 or 2 copies of the short allele of the VNTR interacted with substance use to predict sexual behavior. Substance use had little effect on sexual behavior for youths without the short allele; this effect was greatly increased for youths with the short allele.
Conclusion:
Genetic vulnerability affected the implications of early onset substance use for later sexual behavior.
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