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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Updated: Jun 8, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Perivascular cells as mesenchymal stem cells.

Jifan Feng1, Andrea Mantesso, Paul T Sharpe

  • 1Department of Craniofacial Development and MRC Centre for Transplantation, NIHR comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and Kings College, London, UK.

Expert Opinion on Biological Therapy
|September 15, 2010
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs), crucial for cell therapies, are increasingly identified as pericytes residing in blood vessels. Further research is needed to confirm their differentiation potential and in vivo identity.

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Isolation of Blood-vessel-derived Multipotent Precursors from Human Skeletal Muscle
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Isolation of Blood-vessel-derived Multipotent Precursors from Human Skeletal Muscle

Published on: August 21, 2014

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Last Updated: Jun 8, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Isolation of Blood-vessel-derived Multipotent Precursors from Human Skeletal Muscle
10:52

Isolation of Blood-vessel-derived Multipotent Precursors from Human Skeletal Muscle

Published on: August 21, 2014

Area of Science:

  • Cell Biology
  • Regenerative Medicine
  • Stem Cell Research

Background:

  • Mesenchymal stem cells (MSCs) are multipotent stem cells with significant potential in cell-based therapies due to their differentiation plasticity and immunosuppressive properties.
  • Current identification of MSCs relies on in vitro characteristics, often overlooking their in vivo biological properties and identity.

Purpose of the Study:

  • To review recent advancements in understanding the relationship between pericytes and mesenchymal stem cells.
  • To explore the functional roles and tissue-specific contributions of pericyte-derived MSCs.

Main Methods:

  • Review of recent research on mesenchymal stem cell biology published in the last decade.
  • Analysis of studies identifying MSCs in perivascular locations and their potential identity as pericytes.

Main Results:

  • Evidence suggests MSCs from various tissues are located perivascularly and can be identified as pericytes.
  • The review discusses the link between pericytes and MSCs, including their response to injury and tissue-specific functions.

Conclusions:

  • There is growing consensus linking perivascular cells to MSCs, despite historical debate.
  • Definitive genetic evidence demonstrating pericyte differentiation into various cell types is still required.