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Response of growth differentiation factor-15 to percutaneous coronary intervention and regular exercise training

Peter Scott Munk1, Torstein Valborgland, Noreen Butt

  • 1Department of Cardiology, Stavanger University Hospital, Stavanger, Norway. munk@lyse.net

Scandinavian Cardiovascular Journal : SCJ
|September 15, 2010
PubMed

Insights

Growth Differentiation Factor-15 (GDF-15) transiently increases after percutaneous coronary intervention (PCI). Six months of exercise training did not alter GDF-15, hsTNT, or NT-proBNP levels in stable angina patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • Growth Differentiation Factor-15 (GDF-15) is a cardioprotective cytokine.
  • Its response to percutaneous coronary intervention (PCI) and exercise training is unknown.

Purpose of the Study:

  • To investigate GDF-15 plasma level changes after PCI.
  • To determine the effect of exercise training on GDF-15, hsTNT, and NT-proBNP.

Main Methods:

  • 36 stable angina patients undergoing PCI were randomized to exercise or control groups.
  • Serial measurements of GDF-15, hsTNT, and NT-proBNP were performed post-PCI and during 6-month follow-up.

Main Results:

  • GDF-15 showed a modest, transient increase 30 minutes post-PCI, peaking at 3 hours.
  • hsTNT levels increased significantly at 24 hours post-PCI, normalizing by 7 days.
  • No significant differences in GDF-15, hsTNT, or NT-proBNP changes were observed between groups during follow-up.

Conclusions:

  • Coronary intervention with stent implantation causes a transient increase in GDF-15.
  • Six months of exercise training does not impact GDF-15, hsTNT, or NT-proBNP levels in stable coronary artery disease patients.
Abstract

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