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Updated: Jun 26, 2026

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
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Linking Lipidomics to Vulnerable Coronary Plaques: A PROSPECT II Substudy.

Tania Sharma1,2, Tove Fall3, Sergi Sayols-Baixeras3,4,5

  • 1Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden. (T.S., J.G.S., S.K., R.R., D.E.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

Sphingomyelins are linked to lower coronary plaque burden, while 1-palmitoyl-2-oleoyl-GPE is associated with higher plaque burden in patients with myocardial infarction. These lipidomics findings may aid in developing new diagnostic and therapeutic strategies for atherosclerosis.

Keywords:
atherosclerosislipidomicsmyocardial infarctionsphingomyelinsultrasonography, interventional

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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Area of Science:

  • Cardiovascular Research
  • Metabolomics
  • Lipidomics

Background:

  • Coronary atherosclerosis involves complex metabolic alterations.
  • Understanding vulnerable plaque formation is critical for preventing myocardial infarction.
  • Lipidomics offers insights into metabolic changes associated with coronary artery disease.

Purpose of the Study:

  • To investigate the association between circulating lipid metabolites and imaging-defined features of vulnerable coronary plaque.
  • To identify specific lipid species that correlate with high-risk plaque characteristics.
  • To explore potential diagnostic and therapeutic targets for coronary atherosclerosis.

Main Methods:

  • 877 patients with myocardial infarction underwent 3-vessel coronary artery imaging (near-infrared spectroscopy and intravascular ultrasound).
  • Plasma lipid metabolites (424 species) were quantified using mass spectrometry.
  • Associations between lipid metabolites and plaque metrics (lipid core burden index, plaque burden) were analyzed and validated in the SCAPIS cohort.

Main Results:

  • 156 significant associations (P<0.05) were found between lipid metabolites and coronary plaque characteristics.
  • Sphingomyelins showed an inverse association with all plaque metrics, while 1-palmitoyl-2-oleoyl-GPE (a phosphatidylethanolamine) was positively associated.
  • After multiple testing correction, 27 lipid species remained significant, with sphingomyelins demonstrating the strongest inverse association with lipid burden.

Conclusions:

  • This study first demonstrates a negative association of sphingomyelins and a positive association of 1-palmitoyl-2-oleoyl-GPE with vulnerable coronary plaque features.
  • These findings were validated in an independent cohort using coronary computed tomography angiography.
  • The identified lipid associations may pave the way for novel diagnostic markers and therapeutic interventions for coronary atherosclerosis.