Abnormal F-18 fluoride uptake in intracranial meningiomas on PET/CT

The association between breast carcinoma and meningioma is a well-recognized phenomenon that may have important clinical implications, particularly in intracranial lesions. We report 2 cases of intracranial meningioma in adult women with a history of breast cancer, who were imaged with positron emission tomography/computed tomography (PET/CT) for evaluation of possible bone metastases. Whole-body F-18 fluoride PET demonstrated an intense intracranial focal radiotracer accumulation in both patients. Simultaneous CT showed a corresponding calcified space-occupying lesion, consistent with meningioma. Early and correct diagnosis of synchronous meningioma in F-18 fluoride bone scans might prevent relevant neurologic comorbidity.