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Nondisjunction

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.

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Updated: Jun 8, 2026

Understanding Cerebellar Pattern Formation

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

Dandy-Walker malformation: An incidental finding.

Jyothi Tadakamadla¹, Santhosh Kumar, G P Mamatha

¹Department of Oral Medicine and Radiology, Darshan Dental College and Hospital, Udaipur-313 001, Rajasthan, India.

Indian Journal of Human Genetics

|September 15, 2010

Summary

This summary is machine-generated.

Dandy-Walker malformation (DWM) is a rare brain abnormality affecting the cerebellum. Diagnosis relies on imaging, with this case report highlighting magnetic resonance imaging confirmation.

Keywords:

Dandy–Walker high arch palate hypertelorism

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Area of Science:

Neuroscience
Developmental Biology
Medical Imaging

Background:

Dandy-Walker malformation (DWM) is a congenital brain abnormality impacting cerebellar development.
It involves the cerebellum, cerebellar vermis, and fourth ventricle, leading to an enlarged posterior fossa.

Observation:

DWM presents with a wide range of clinical signs, none of which are pathognomonic.
Definitive diagnosis is contingent upon neuroimaging.
This report details a specific case diagnosed via MRI.

Findings:

Magnetic resonance imaging (MRI) is a key diagnostic tool for Dandy-Walker malformation.
The case presented demonstrated characteristic imaging findings consistent with DWM.
No pathognomonic clinical signs were identified pre-diagnosis.

Implications:

Accurate diagnosis of DWM through advanced imaging like MRI is crucial for patient management.
Understanding the imaging characteristics aids in differentiating DWM from other posterior fossa anomalies.
This case contributes to the literature on DWM diagnosis and neuroimaging