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Published on: April 3, 2026
Uterine C-Kit positive low grade stromal sarcoma.
Jovitha Martin1, Anita Ramesh, Sarah Kuruvilla
1Departments of Oncology, Sri Ramachandra Medical College, Chennai, India.
Summary
This rare case highlights a uterine sarcoma positive for C-Kit (CD117) in a post-menopausal woman. The study discusses the diagnostic challenges and management of this uncommon malignancy.
Area of Science:
- Gynecologic Oncology
- Surgical Pathology
- Oncologic Imaging
Background:
- Uterine C-Kit positive stromal tumors are uncommon gynecologic malignancies.
- Early diagnosis and treatment are crucial for patient outcomes.
Observation:
- A 58-year-old post-menopausal woman presented with vaginal bleeding and an enlarged uterus.
- Imaging revealed a large uterine mass with potential spread to an aortocaval lymph node and bone lesions.
Findings:
- Biopsy of the uterine mass confirmed a low-grade uterine sarcoma.
- Immunohistochemistry showed positivity for C-Kit (CD117), a key diagnostic marker.
Implications:
- This case underscores the importance of considering rare diagnoses in gynecologic oncology.
- The management of such rare uterine sarcomas presents a significant clinical dilemma.
