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Pseudomonas diarrhea in a child suffering from acute lymphatic leukemia

A De1, H Mathurkar, S Baveja

  • 1Department of Microbiology, L.T.M. Medical College, Sion, Mumbai, India.

Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology
|September 15, 2010
PubMed

Insights

Pseudomonas aeruginosa infections can cause diarrhea in children with acute lymphatic leukemia. Routine stool cultures for leukemia patients with diarrhea are crucial for timely diagnosis and treatment.

Area of Science:

  • Pediatric Oncology
  • Infectious Diseases

Background:

  • Acute lymphatic leukemia (CALLA positive) is a significant diagnosis in pediatric patients.
  • Immunocompromised states, common in leukemia patients undergoing chemotherapy, increase susceptibility to opportunistic infections.

Observation:

  • A pediatric patient diagnosed with acute lymphatic leukemia presented with loose motions.
  • Stool and blood cultures confirmed the presence of Pseudomonas aeruginosa.
  • Diarrhea resolved within five days, but Pseudomonas aeruginosa persisted in stool cultures for over a month despite treatment.

Findings:

  • While rare, Pseudomonas aeruginosa can cause diarrhea, particularly in immunocompromised individuals.
  • The infection is potentially linked to neutropenic enterocolitis, a serious complication in cancer patients.
  • Persistent Pseudomonas aeruginosa in stool highlights challenges in eradicating infections in this population.

Implications:

  • Routine stool cultures are recommended for all leukemia patients on chemotherapy experiencing diarrhea.
  • Early and accurate identification of pathogens like Pseudomonas aeruginosa enables targeted antibiotic therapy.
  • Implementing routine stool cultures can reduce morbidity and mortality in pediatric leukemia patients by ensuring appropriate management of infectious complications.

Keywords:
Acute lymphatic leukemiaPseudomonasdiarrhea

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